Expression of LIF and LIF receptor beta in Alzheimer’s and Parkinson’s diseases
Identifieur interne : 000722 ( Main/Exploration ); précédent : 000721; suivant : 000723Expression of LIF and LIF receptor beta in Alzheimer’s and Parkinson’s diseases
Auteurs : M. Soilu-H Nninen ; E. Broberg ; M. Röytt ; P. Mattila ; J. Rinne [Finlande] ; V. Hukkanen [Finlande]Source :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2010-01.
English descriptors
Abstract
Background – Signaling through the leukemia inhibitory factor (LIF) receptor (LIFR) is crucial for nervous system development. There are few studies concerning the expression of LIF and LIFR in normal and degenerating adult human brain. Objectives – To study the expression of LIF and LIFR in Alzheimer’s disease (AD), Parkinson’s disease (PD), and control brains. Patients and methods – LIF and LIFR mRNA copy numbers were determined by quantitative real‐time RT‐PCR from four brain regions of 34 patients with AD, 40 patients with PD, and 40 controls. Immunohistochemistry was performed in seven PD and in four AD patients and in seven normal controls. Results – In general, the LIF copy numbers were 1 log higher than the LIFR copy numbers. In the AD brains, LIF expression was higher than in the controls in the hippocampus and in the temporal cortex, and in the PD brains in the hippocampus and in the anterior cingulated cortex. Expressions of LIF and LIFR in different brain regions were opposite except for the AD hippocampus and PD anterior cingulated cortex, where the expression patterns were parallel. Conclusions – Co‐operative expression of LIF and LIFR in AD hippocampus and PD anterior cingulated cortex may indicate a role for LIF in neuronal damage or repair in these sites.
Url:
DOI: 10.1111/j.1600-0404.2009.01179.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression of LIF and LIF receptor beta in Alzheimer’s and Parkinson’s diseases</title><author><name sortKey="Soilu Nninen, M" sort="Soilu Nninen, M" uniqKey="Soilu Nninen M" first="M." last="Soilu-H Nninen">M. Soilu-H Nninen</name></author><author><name sortKey="Broberg, E" sort="Broberg, E" uniqKey="Broberg E" first="E." last="Broberg">E. Broberg</name></author><author><name sortKey="Roytt, M" sort="Roytt, M" uniqKey="Roytt M" first="M." last="Röytt">M. Röytt</name></author><author><name sortKey="Mattila, P" sort="Mattila, P" uniqKey="Mattila P" first="P." last="Mattila">P. Mattila</name></author><author><name sortKey="Rinne, J" sort="Rinne, J" uniqKey="Rinne J" first="J." last="Rinne">J. Rinne</name></author><author><name sortKey="Hukkanen, V" sort="Hukkanen, V" uniqKey="Hukkanen V" first="V." last="Hukkanen">V. Hukkanen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1F00304B44388DAE51D67B2495FE968F1241C512</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1600-0404.2009.01179.x</idno><idno type="url">https://api.istex.fr/document/1F00304B44388DAE51D67B2495FE968F1241C512/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001951</idno><idno type="wicri:Area/Main/Curation">001700</idno><idno type="wicri:Area/Main/Exploration">000722</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Expression of LIF and LIF receptor beta in Alzheimer’s and Parkinson’s diseases</title><author><name sortKey="Soilu Nninen, M" sort="Soilu Nninen, M" uniqKey="Soilu Nninen M" first="M." last="Soilu-H Nninen">M. Soilu-H Nninen</name><affiliation><wicri:noCountry code="no comma">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Broberg, E" sort="Broberg, E" uniqKey="Broberg E" first="E." last="Broberg">E. Broberg</name><affiliation><wicri:noCountry code="no comma">Department of Virology</wicri:noCountry></affiliation></author><author><name sortKey="Roytt, M" sort="Roytt, M" uniqKey="Roytt M" first="M." last="Röytt">M. Röytt</name><affiliation><wicri:noCountry code="no comma">Department of Pathology</wicri:noCountry></affiliation></author><author><name sortKey="Mattila, P" sort="Mattila, P" uniqKey="Mattila P" first="P." last="Mattila">P. Mattila</name><affiliation><wicri:noCountry code="no comma">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Rinne, J" sort="Rinne, J" uniqKey="Rinne J" first="J." last="Rinne">J. Rinne</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku PET Centre, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Hukkanen, V" sort="Hukkanen, V" uniqKey="Hukkanen V" first="V." last="Hukkanen">V. Hukkanen</name><affiliation><wicri:noCountry code="no comma">Department of Virology</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Microbiology, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-01">2010-01</date><biblScope unit="volume">121</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="44">44</biblScope><biblScope unit="page" to="50">50</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">1F00304B44388DAE51D67B2495FE968F1241C512</idno><idno type="DOI">10.1111/j.1600-0404.2009.01179.x</idno><idno type="ArticleID">ANE1179</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer’s disease</term><term>Parkinson’s disease</term><term>molecular biology</term><term>neuropathology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background – Signaling through the leukemia inhibitory factor (LIF) receptor (LIFR) is crucial for nervous system development. There are few studies concerning the expression of LIF and LIFR in normal and degenerating adult human brain. Objectives – To study the expression of LIF and LIFR in Alzheimer’s disease (AD), Parkinson’s disease (PD), and control brains. Patients and methods – LIF and LIFR mRNA copy numbers were determined by quantitative real‐time RT‐PCR from four brain regions of 34 patients with AD, 40 patients with PD, and 40 controls. Immunohistochemistry was performed in seven PD and in four AD patients and in seven normal controls. Results – In general, the LIF copy numbers were 1 log higher than the LIFR copy numbers. In the AD brains, LIF expression was higher than in the controls in the hippocampus and in the temporal cortex, and in the PD brains in the hippocampus and in the anterior cingulated cortex. Expressions of LIF and LIFR in different brain regions were opposite except for the AD hippocampus and PD anterior cingulated cortex, where the expression patterns were parallel. Conclusions – Co‐operative expression of LIF and LIFR in AD hippocampus and PD anterior cingulated cortex may indicate a role for LIF in neuronal damage or repair in these sites.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><noCountry><name sortKey="Broberg, E" sort="Broberg, E" uniqKey="Broberg E" first="E." last="Broberg">E. Broberg</name><name sortKey="Mattila, P" sort="Mattila, P" uniqKey="Mattila P" first="P." last="Mattila">P. Mattila</name><name sortKey="Roytt, M" sort="Roytt, M" uniqKey="Roytt M" first="M." last="Röytt">M. Röytt</name><name sortKey="Soilu Nninen, M" sort="Soilu Nninen, M" uniqKey="Soilu Nninen M" first="M." last="Soilu-H Nninen">M. Soilu-H Nninen</name></noCountry><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Rinne, J" sort="Rinne, J" uniqKey="Rinne J" first="J." last="Rinne">J. Rinne</name></region><name sortKey="Hukkanen, V" sort="Hukkanen, V" uniqKey="Hukkanen V" first="V." last="Hukkanen">V. Hukkanen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000722 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000722 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1F00304B44388DAE51D67B2495FE968F1241C512
|texte= Expression of LIF and LIF receptor beta in Alzheimer’s and Parkinson’s diseases
}}
| This area was generated with Dilib version V0.6.23. |  |